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Invitrogen

Phospho-PI3K p85 alpha (Tyr580) Polyclonal Antibody

View all (31) PI3K p85 alpha antibodies

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Phospho-PI3K p85 alpha (Tyr580) Polyclonal Antibody

Product Details

PA5-105114

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PIK3R1(Accession P27986), corresponding to amino acid residues around phosphorylated Tyr580.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816587

Product Specific Information

Antibody detects endogenous levels of PI3K p85 alpha only when phosphorylated at Tyr580.

Target Information

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: p55-GAMMA; p55PIK; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI3-kinase p85 subunit alpha; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; polypeptide 1 p85 alpha; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-alpha; RP4-533D7.2

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Gene Aliases: GRB1; p50alpha; p55alpha; p85alpha; PI3K; PI3KA; PIK3R1

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UniProt ID: (Mouse) P26450, (Rat) Q63787

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Entrez Gene ID: (Mouse) 18708, (Rat) 25513

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Function(s)
receptor binding insulin receptor binding insulin-like growth factor receptor binding platelet-derived growth factor receptor binding neurotrophin TRKA receptor binding protein binding calmodulin binding protein C-terminus binding transcription factor binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding estrogen receptor binding receptor tyrosine kinase binding ubiquitin protein ligase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity ATPase binding phosphoprotein binding kinase modulator
Process(es)
cellular glucose homeostasis positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion glucose metabolic process protein phosphorylation transport negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of heart rate positive regulation of gene expression negative regulation of muscle cell apoptotic process phosphatidylinositol 3-kinase signaling protein transport negative regulation of cell-cell adhesion B cell differentiation positive regulation of cell migration positive regulation of tumor necrosis factor production response to insulin cellular response to insulin stimulus positive regulation of RNA splicing cellular response to UV response to endoplasmic reticulum stress phosphatidylinositol-3-phosphate biosynthetic process positive regulation of transcription factor import into nucleus negative regulation of apoptotic process regulation of phosphatidylinositol 3-kinase activity positive regulation of myoblast differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell proliferation protein stabilization response to glucocorticoid regulation of stress fiber assembly NFAT protein import into nucleus response to cAMP growth hormone receptor signaling pathway regulation of establishment of protein localization to plasma membrane positive regulation of endoplasmic reticulum unfolded protein response response to yeast aging response to nutrient response to fructose response to iron(II) ion response to estradiol response to progesterone response to testosterone response to drug response to amino acid response to ethanol response to fatty acid response to growth factor cellular response to fatty acid response to dexamethasone
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