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Invitrogen
Phospho-Ku70 (Ser520) Polyclonal Antibody
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Phospho-Ku70 (Ser520) Antibody (PA5-105148) in ICC/IF
Immunofluorescent analysis of Phospho-Ku70 (Ser520) in HepG2 cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Ku70 (Ser520) polyclonal antibody (Product # PA5-105148) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105148
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human XRCC6(Accession P12956), corresponding to amino acid residues around phosphorylated Ser520.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of Ku70 only when phosphorylated at Ser520.
靶标信息
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CT; CTA-216E10.7; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein Ku70; DNA repair protein XRCC6; Ku autoantigen protein p70 homolog; Ku p70; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Lupus Ku autoantigen protein p70; OTTHUMP00000028581; thyroid autoantigen; thyroid autoantigen 70 kDa; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
基因别名: 70kDa; G22P1; Ku70; Kup70; XRCC6
UniProt ID: (Mouse) P23475
Entrez Gene ID: (Rat) 25019, (Mouse) 14375
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
protein binding
protein C-terminus binding
telomeric DNA binding
transcription regulatory region DNA binding
poly(A) RNA binding
5'-deoxyribose-5-phosphate lyase activity
nucleotide binding
DNA binding
catalytic activity
helicase activity
ATP binding
hydrolase activity
lyase activity
DNA helicase
telomere maintenance
double-strand break repair
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
brain development
response to ionizing radiation
DNA duplex unwinding
V(D)J recombination
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of neurogenesis
cellular hyperosmotic salinity response
cellular response to X-ray
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
metabolic process
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