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Invitrogen
Phospho-MOB1B (Thr12) Polyclonal Antibody
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Phospho-MOB1B (Thr12) Antibody (PA5-105218) in WB
Western blot analysis of Phospho-MOB4A (Thr12) in 293 treated with IFN (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-MOB4A (Thr12) polyclonal antibody (Product # PA5-105218).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105218
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MOB1B(Accession Q7L9L4), corresponding to amino acid residues around phosphorylated Thr12.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of MOB1A only when phosphorylated at Thr12.
靶标信息
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MOB kinase activator 1B; Mob1 homolog 1A; MOB1, Mps One Binder kinase activator-like 1A; Mob1A; Mob1B; MOB4A; MOBKL1A; Mps one binder kinase activator-like 1A
基因别名: 1110003E08Rik; AU015450; B230364F10; MOB1B; MOB4A; MOBKL1A
UniProt ID: (Mouse) Q8BPB0
Entrez Gene ID: (Rat) 360920, (Mouse) 68473
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