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Invitrogen
Phospho-BABAM1 (Ser29) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-BABAM1 (Ser29) Antibody (PA5-105236) in WB
Western blot analysis of Phospho-BABAM1 (Ser29) in extracts from HepG2 cells (LPS 4h treatment). Samples were incubated with Phospho-BABAM1 (Ser29) polyclonal antibody (Product # PA5-105236). The lane on the left was treated with blocking peptide.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105236
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BABAM1(Accession Q9NWV8), corresponding to amino acid residues around phosphorylated Ser29.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of MERIT40 only when phosphorylated at Ser29.
Target Information
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1-A complex subunit MERIT40; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1-A complex; new component of the BRCAA1 A complex; unnamed protein product
Gene Aliases: 5430437P03Rik; C19orf62; HSPC142; MERIT40; NBA1
UniProt ID: (Human) Q9NWV8, (Rat) Q5XIJ6, (Mouse) Q3UI43
Entrez Gene ID: (Human) 29086, (Rat) 290631, (Mouse) 68251
Disclaimer
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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