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Invitrogen
Phospho-CTGF (Ser118) Polyclonal Antibody
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FIGURE: 1 / 4
Phospho-CTGF (Ser118) Antibody (PA5-105312) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-CTGF (Ser118) in mouse kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-CTGF (Ser118) polyclonal antibody (Product # PA5-105312) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CTGF(Accession P29279), corresponding to amino acid residues around phosphorylated Ser118.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of CTGF only when phosphorylated at Ser118.
Target Information
Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-Nov; cellular communication network factor 1; connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); connective tissue growth-related protein; CTGF; CTGRP; fibroblast inducible secreated protein; fibroblast inducible secreted protein; H-CTGF; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24; IGF-binding protein 8; insulin-like growth factor-binding protein 8; MGC102839; unnamed protein product
Gene Aliases: CTGF; CTGRP; fisp-12; Fisp12; HCS24; IBP-8; IGFBP8; KMD; NOV2; SEMDLSL
UniProt ID: (Human) P29279, (Mouse) P29268, (Rat) Q9R1E9
Entrez Gene ID: (Human) 1490, (Mouse) 14219, (Rat) 64032
osteoblast differentiation
cell adhesion
signal transduction
epidermis development
response to wounding
positive regulation of cell differentiation
positive regulation of JNK cascade
regulation of developmental process
positive regulation of stress fiber assembly
positive regulation of ERK1 and ERK2 cascade
cartilage condensation
ossification
angiogenesis
tissue homeostasis
positive regulation of protein phosphorylation
microtubule depolymerization
cell-matrix adhesion
integrin-mediated signaling pathway
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
cell migration
cell differentiation
lung development
regulation of chondrocyte differentiation
positive regulation of collagen biosynthetic process
intracellular signal transduction
chondrocyte proliferation
positive regulation of cell activation
regulation of multicellular organismal process
positive regulation of cardiac muscle contraction
connective tissue development
extracellular matrix constituent secretion
positive regulation of G0 to G1 transition
reactive oxygen species metabolic process
calcium ion transmembrane import into cytosol
positive regulation of apoptotic signaling pathway
response to gamma radiation
response to estradiol
response to anoxia
cellular response to interleukin-13
response to amino acid
response to peptide hormone
response to mineralocorticoid
response to fatty acid
cellular response to glucose stimulus
cellular response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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