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Invitrogen

Phospho-FMRP (Ser500) Polyclonal Antibody

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Phospho-FMRP (Ser500) Polyclonal Antibody

Product Details

PA5-105341

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FMR1(Accession Q06787), corresponding to amino acid residues around phosphorylated Ser500.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816769

Product Specific Information

Antibody detects endogenous levels of FMR1 only when phosphorylated at Ser500.

Target Information

FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternative splicing of exon 15; exons 15, 16 and 17; FMRP; FMRP translational regulator 1; FMRP; contains neo-disrupted exon 5; alternatively spliced; MGC87458; protein FMR-1; RNA-binding protein; similar to fragile X mental retardation protein.; synaptic functional regulator FMR1; translational regulator; synaptic functional regulator; unnamed protein product; with exon 12; without exon 12

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Gene Aliases: Fmr-1; FMRP; FRAXA; POF; POF1

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UniProt ID: (Human) Q06787, (Rat) Q80WE1, (Mouse) P35922

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Entrez Gene ID: (Human) 2332, (Rat) 24948, (Mouse) 14265

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Function(s)
G-quadruplex RNA binding nucleic acid binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding microtubule binding poly(U) RNA binding translation repressor activity translation initiation factor binding RNA strand annealing activity poly(G) binding siRNA binding miRNA binding signaling adaptor activity RNA stem-loop binding identical protein binding protein homodimerization activity ribosome binding ion channel binding macromolecular complex binding translation regulator activity protein heterodimerization activity mRNA 5'-UTR binding dynein complex binding histone H3 reader activity molecular condensate scaffold activity N6-methyladenosine-containing RNA binding sequence-specific mRNA binding RNA 7-methylguanosine cap binding poly(A) binding protein kinase binding protein phosphatase binding protein domain specific binding
Process(es)
regulation of alternative mRNA splicing, via spliceosome ovarian follicle development positive regulation of protein phosphorylation negative regulation of receptor internalization positive regulation of receptor internalization DNA repair chromatin organization mRNA export from nucleus regulation of translation glutamate receptor signaling pathway central nervous system development response to light stimulus positive regulation of gene expression negative regulation of gene expression negative regulation of protein processing response to activity negative regulation of translation transmission of nerve impulse regulation of proteolysis stress granule assembly response to gonadotropin social behavior gene silencing by miRNA locomotory exploration behavior cellular response to potassium ion response to cocaine regulation of mRNA stability negative regulation of neuron apoptotic process modulation by host of viral RNA genome replication negative regulation of neuron differentiation positive regulation of translation negative regulation of translational initiation regulation of neurotransmitter secretion positive regulation of long-term neuronal synaptic plasticity animal organ development regulation of developmental process positive regulation of synaptic transmission detection of mechanical stimulus involved in sensory perception mRNA transport negative regulation of protein metabolic process regulation of filopodium assembly positive regulation of filopodium assembly response to electrical stimulus skeletal muscle organ development negative regulation of gene silencing by miRNA dendritic spine development regulation of dendritic spine development positive regulation of dendritic spine development response to interleukin-1 glutamate homeostasis response to interleukin-17 cellular response to virus evoked excitatory postsynaptic potential regulation of neuronal action potential excitatory chemical synaptic transmission inhibitory chemical synaptic transmission regulation of translation at synapse, modulating synaptic transmission regulation of translation at presynapse, modulating synaptic transmission regulation of translation at postsynapse, modulating synaptic transmission membraneless organelle assembly positive regulation of long-term synaptic potentiation regulation of long term synaptic depression negative regulation of long term synaptic depression positive regulation of long term synaptic depression positive regulation of intracellular transport of viral material negative regulation of voltage-gated calcium channel activity positive regulation of proteasomal protein catabolic process cellular response to L-glutamate negative regulation of synaptic vesicle exocytosis positive regulation of gene silencing by miRNA negative regulation of cytoplasmic translation regulation of cell communication positive regulation of cellular component organization regulation of mRNA metabolic process deadenylation-dependent decapping of nuclear-transcribed mRNA
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