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Invitrogen
Phospho-GATA2 (Ser192) Polyclonal Antibody
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FIGURE: 1 / 4
Phospho-GATA2 (Ser192) Antibody (PA5-105538) in ICC/IF
Immunofluorescent analysis of Phospho-GATA2 (Ser192) in HepG2 cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-GATA2 (Ser192) polyclonal antibody (Product # PA5-105538) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 5... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105538
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GATA2(Accession P23769), corresponding to amino acid residues around phosphorylated Ser192.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of GATA2 only when phosphorylated at Ser192.
Target Information
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; GATA-bindning protein 2; gata2 {ECO:0000312|EMBL:AAK51128.1}; MGC2306
Gene Aliases: Gata-2; GATA2
UniProt ID: (Mouse) O09100, (Rat) Q924Y4
Entrez Gene ID: (Mouse) 14461, (Rat) 25159
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger domain binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
phagocytosis
positive regulation of cytosolic calcium ion concentration
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
hemopoiesis
cell differentiation
neuron differentiation
somatic stem cell population maintenance
regulation of histone acetylation
eosinophil fate commitment
inner ear morphogenesis
mast cell degranulation
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
neuron fate commitment
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
negative regulation of fat cell proliferation
GABAergic neuron differentiation
negative regulation of neural precursor cell proliferation
regulation of forebrain neuron differentiation
response to lipid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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