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Invitrogen

Phospho-CK2 alpha-1 (Tyr360) Polyclonal Antibody

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Phospho-CK2 alpha-1 (Tyr360) Polyclonal Antibody

Product Details

PA5-105602

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CSNK2A1(Accession P68400), corresponding to amino acid residues around phosphorylated Thr360.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817030

Product Specific Information

Antibody detects endogenous levels of CKII alpha only when phosphorylated at Thr360.

Target Information

CSNK2A1 is a serine/threonine protein kinase that phosphorylates acidic proteins. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by CK2 alpha-1 represents the alpha subunit. While CK2 alpha-1 is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for CK2 alpha-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: casein kinase 2 alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; casein kinase II, alpha 1 related sequence 4; CK II alpha; CK2 catalytic subunit alpha; protein kinase CK2; protein kinase; CK2 alpha''; unnamed protein product

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Gene Aliases: CK2A1; Cka1; Cka2; CKII; Ckiia; CSNK2A1; Csnk2a1-rs4; OCNDS

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UniProt ID: (Human) P68400, (Mouse) Q60737, (Rat) P19139

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Entrez Gene ID: (Human) 1457, (Mouse) 12995, (Rat) 116549

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity identical protein binding Hsp90 protein binding protein serine kinase activity beta-catenin binding protein phosphatase regulator activity protein N-terminus binding
Process(es)
DNA damage checkpoint deadenylation-dependent decapping of nuclear-transcribed mRNA double-strand break repair via homologous recombination double-strand break repair regulation of transcription from RNA polymerase II promoter protein folding apoptotic process cellular response to DNA damage stimulus signal transduction positive regulation of cell proliferation Wnt signaling pathway negative regulation of translation protein catabolic process positive regulation of Wnt signaling pathway positive regulation of cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aggrephagy regulation of protein catabolic process positive regulation of protein catabolic process negative regulation of translational initiation rhythmic process protein stabilization regulation of cell cycle protein targeting to vacuole involved in autophagy symbiont-mediated disruption of host cell PML body execution phase of apoptosis double-strand break repair via classical nonhomologous end joining membraneless organelle assembly negative regulation of signal transduction by p53 class mediator positive regulation of aggrephagy regulation of chromosome separation protein localization to site of double-strand break negative regulation of double-strand break repair via homologous recombination negative regulation of apoptotic signaling pathway protein phosphorylation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein autophosphorylation regulation of catalytic activity mitotic spindle checkpoint regulation of cell growth transcription, DNA-templated regulation of transcription, DNA-templated regulation of cell proliferation
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