Search

  • Contact Us
  • Quick Order

Invitrogen

Phospho-alpha Dystroglycan (Tyr892) Polyclonal Antibody

View all (6) alpha Dystroglycan antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

{{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
Phospho-alpha Dystroglycan (Tyr892) Polyclonal Antibody

Product Details

PA5-105944

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DAG1(Accession Q14118), corresponding to amino acid residues around phosphorylated Tyr892.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817343

Product Specific Information

Antibody detects endogenous levels of DAG1 only when phosphorylated at Tyr892.

Target Information

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: alpha-dystroglycan; beta-dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; unnamed protein product

View more View less

Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DG; Dp427; Dp71; LGMDR16; MDDGA9; MDDGC7; MDDGC9

View more View less

UniProt ID: (Human) Q14118, (Mouse) Q62165

View more View less

Entrez Gene ID: (Human) 1605, (Rat) 114489, (Mouse) 13138

View more View less

Function(s)
virus receptor activity dystroglycan binding actin binding serine-type endopeptidase activity laminin receptor activity calcium ion binding protein binding structural constituent of muscle tubulin binding vinculin binding signaling receptor activity SH2 domain binding laminin binding laminin-1 binding heparan sulfate proteoglycan binding macromolecular complex binding alpha-actinin binding identical protein binding
Process(es)
positive regulation of cell-matrix adhesion morphogenesis of an epithelium morphogenesis of an epithelial sheet heart morphogenesis membrane protein ectodomain proteolysis cell surface receptor signaling pathway axon guidance synapse assembly heart development Schwann cell differentiation Schwann cell development response to muscle activity response to denervation involved in regulation of muscle adaptation protein transport muscle attachment calcium-dependent cell-matrix adhesion nerve development nerve maturation myelination in peripheral nervous system negative regulation of cell migration axon regeneration positive regulation of myelination microtubule anchoring positive regulation of Rac protein signal transduction protein localization to synapse skeletal muscle tissue regeneration negative regulation of MAPK cascade response to peptide hormone positive regulation of protein kinase activity viral entry into host cell regulation of synaptic plasticity positive regulation of oligodendrocyte differentiation regulation of synapse organization synaptic growth at neuromuscular junction positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling angiogenesis involved in wound healing epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis cellular response to mechanical stimulus cellular response to cholesterol commissural neuron axon guidance basement membrane organization extracellular matrix assembly regulation of neurotransmitter receptor localization to postsynaptic specialization membrane retrograde trans-synaptic signaling by trans-synaptic protein complex positive regulation of skeletal muscle acetylcholine-gated channel clustering inhibitory synapse assembly negative regulation of synaptic transmission, cholinergic chondrocyte differentiation cell adhesion negative regulation of muscle cell apoptotic process extracellular matrix organization camera-type eye development synaptic signaling
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support