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Invitrogen

Phospho-CDK5 (Ser159) Polyclonal Antibody

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Phospho-CDK5 (Ser159) Polyclonal Antibody

Product Details

PA5-106081

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDK5(Accession Q00535), corresponding to amino acid residues around phosphorylated Ser159.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817480

Product Specific Information

Antibody detects endogenous levels of CDK5 only when phosphorylated at Ser159.

Target Information

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

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Gene Aliases: AW048668; CDK5; CDKN5; Crk6; PSSALRE

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UniProt ID: (Mouse) P49615, (Rat) Q03114

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Entrez Gene ID: (Mouse) 12568, (Rat) 140908

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Function(s)
nucleotide binding p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding cytoskeletal protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding acetylcholine receptor activator activity ErbB-3 class receptor binding ephrin receptor binding tau-protein kinase activity non-receptor serine/threonine protein kinase
Process(es)
neuron migration synaptic transmission, dopaminergic protein phosphorylation intracellular protein transport exocytosis nucleocytoplasmic transport apoptotic process cell cycle cell-matrix adhesion nervous system development axonogenesis synapse assembly skeletal muscle tissue development motor neuron axon guidance associative learning visual learning response to wounding Schwann cell development phosphorylation cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain telencephalon development cerebellum development cerebellar cortex development cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development cerebral cortex development corpus callosum development neuron differentiation regulation of cell migration negative regulation of axon extension cortical actin cytoskeleton organization forebrain development neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse response to cocaine receptor clustering positive regulation of neuron apoptotic process regulated exocytosis negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process oligodendrocyte differentiation neuron projection morphogenesis dendrite morphogenesis cell division neuron apoptotic process regulation of cell cycle regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import positive regulation of protein targeting to membrane negative regulation of neuron death positive regulation of receptor activity central nervous system development axon extension
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