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Invitrogen
Phospho-GABBR2 (Ser884) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-GABBR2 (Ser884) Antibody (PA5-106086) in ICC/IF
Immunocytochemistry analysis of Phospho-GABBR2 (Ser884) in Hela cells (Etoposide 25 μm for 5h). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-GABBR2 (Ser884) polyclonal antibody (Product # PA5-106086) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-ra... View More
Product Details
PA5-106086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GABBR2(Accession O75899), corresponding to amino acid residues around phosphorylated Ser884.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of GABBR2 only when phosphorylated at Ser884.
Target Information
The multi-pass membrane protein, GABBR2, belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ36928; G protein-coupled metabotropic GABA receptor; G protein-coupled receptor; G protein-coupled receptor 51; G-protein coupled receptor 51; GABA BR; GABA-B R2 receptor; GABA-B receptor 2; GABA-B receptor, R2 subunit; GABA-B-R2; GABA-BR2; GABABR2; GABBR2; GABA B receptor 2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor, 2; gamma-aminobutyric acid B receptor 2; Gamma-aminobutyric acid type B receptor subunit 2; gamma-aminobutyric acid type B receptor, subunit 2; gb2; HG20; HRIHFB2099; MGC119386; MGC119388; MGC119389; ortholog of human G protein-coupled receptor 51 GPR51; RP23-337N2.1
Gene Aliases: DEE59; EIEE59; GABABR2; GABBR2; Gb2; Gm425; GPR51; GPRC3B; HG20; HRIHFB2099; NDPLHS
UniProt ID: (Human) O75899, (Rat) O88871, (Mouse) Q80T41
Entrez Gene ID: (Human) 9568, (Rat) 83633, (Mouse) 242425
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
synaptic transmission, GABAergic
neuron-glial cell signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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