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Invitrogen

Phospho-Met (Tyr1365) Polyclonal Antibody

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Phospho-Met (Tyr1365) Polyclonal Antibody

Product Details

PA5-106097

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MET(Accession P08581), corresponding to amino acid residues around phosphorylated Tyr1365.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817496

Product Specific Information

Antibody detects endogenous levels of c-Met only when phosphorylated at Tyr1365.

Target Information

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Met; cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met oncogene; MET proto-oncogene protein; met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; tyrosine kinase; hepatocyte growth factor receptor; HGFR; Tyrosine-protein kinase Met; unnamed protein product

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Gene Aliases: AI838057; AUTS9; c-Met; DA11; DFNB97; HGF; HGFR; MET; Par4; RCCP2

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UniProt ID: (Human) P08581, (Rat) P97523

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Entrez Gene ID: (Human) 4233, (Rat) 24553, (Mouse) 17295

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity protein binding ATP binding kinase activity transferase activity semaphorin receptor activity protein phosphatase binding identical protein binding molecular function activator activity beta-catenin binding protein complex binding phospholipase binding phosphatidylinositol 3-kinase binding protein heterodimerization activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
endothelial cell morphogenesis liver development signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway regulation of gene expression negative regulation of autophagy neuron differentiation pancreas development positive regulation of microtubule polymerization negative regulation of Rho protein signal transduction positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway cell development animal organ development branching morphogenesis of an epithelial tube positive chemotaxis negative regulation of stress fiber assembly excitatory postsynaptic potential establishment of skin barrier negative regulation of thrombin receptor signaling pathway semaphorin-plexin signaling pathway negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of guanyl-nucleotide exchange factor activity positive regulation of endothelial cell chemotaxis negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity neuron migration placenta development brain development muscle organ development skeletal muscle tissue development cell aging lactation male gonad development response to wounding response to acidic pH positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transport positive regulation of neuron projection development oligodendrocyte development response to organic cyclic compound muscle cell migration myotube differentiation peptidyl-tyrosine phosphorylation central nervous system neuron differentiation sperm motility adult behavior positive regulation of peptidyl-serine phosphorylation response to drug glucose homeostasis response to peptide hormone positive regulation of DNA replication positive regulation of mitotic nuclear division protein autophosphorylation positive regulation of dendrite morphogenesis modulation of synaptic transmission myoblast proliferation regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling cellular response to inorganic substance cellular response to arsenic-containing substance cellular response to glucose stimulus cellular response to interleukin-6 cellular response to growth factor stimulus cellular response to peptide hormone stimulus protein phosphorylation phosphorylation
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