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Invitrogen
JMY Polyclonal Antibody
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FIGURE: 1 / 3
JMY Antibody (PA5-106460) in WB
Western blot analysis of JMY in extracts from various samples. Samples were incubated with JMY polyclonal antibody (Product # PA5-106460). Lane 1: Mouse brain, blocked with antigen-specific peptides; Lane 2: Mouse brain; Lane 3: Rat brain; Lane 4: Mouse kidney; Lane 5: A549 cells (heat shock treatment).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106460
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human JMY(Accession Q8N9B5), corresponding to amino acid residues E945-N988.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total JMY.
Target Information
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ37870; Junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY; similar to junction-mediating and regulatory protein
Gene Aliases: JMY
UniProt ID: (Mouse) Q9QXM1
Entrez Gene ID: (Mouse) 57748, (Rat) 683593
DNA repair
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
cell cycle arrest
Arp2/3 complex-mediated actin nucleation
positive regulation of apoptotic process
regulation of DNA-templated transcription in response to stress
positive regulation of sequence-specific DNA binding transcription factor activity
'de novo' actin filament nucleation
actin polymerization-dependent cell motility
intrinsic apoptotic signaling pathway by p53 class mediator
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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