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Invitrogen
LRP8 Polyclonal Antibody
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FIGURE: 1 / 3
LRP8 Antibody (PA5-106821) in IHC (P)
Immunohistochemistry analysis of LRP8 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with LRP8 polyclonal antibody (Product # PA5-106821) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LRP8(Accession Q14114), corresponding to amino acid residues V457-V507.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LRP8.
Target Information
Apolipoprotein E receptor 2 (ApoER2) is an NMDA associated protein found in neurons. It participates in important functions from guiding neurons in the embryonic brain to regulating synaptic signaling. It is also involved in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apolipoprotein E receptor 2; low density lipoprotein receptor relative, 8 ligand binding repeats, brain; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Low-density lipoprotein receptor-related protein 8; LRP-8
Gene Aliases: 4932703M08Rik; AA921429; AI848122; APOER2; Lr8b; LRP8
UniProt ID: (Mouse) Q924X6
Entrez Gene ID: (Rat) 362558, (Mouse) 16975
glycoprotein binding
calcium ion binding
high-density lipoprotein particle binding
kinesin binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
reelin receptor activity
calcium-dependent protein binding
low-density lipoprotein receptor activity
protein binding
apolipoprotein
negative regulation of transcription from RNA polymerase II promoter
endocytosis
receptor-mediated endocytosis
ammon gyrus development
hippocampus development
layer formation in cerebral cortex
cerebral cortex development
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
response to drug
positive regulation of protein kinase activity
positive regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
cellular response to growth factor stimulus
cellular response to cholesterol
positive regulation of dendrite development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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