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Invitrogen
NeuroD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106870
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NEUROD1(Accession Q13562), corresponding to amino acid residues M1-D31.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NEUROD1.
靶标信息
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; Beta-cell E-box transcriptional activator 2; Beta2; BHF-1; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; unnamed protein product
基因别名: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1; T2D
UniProt ID: (Rat) Q64289, (Mouse) Q60867
Entrez Gene ID: (Human) 4760, (Rat) 29458, (Mouse) 18012
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
double-stranded DNA binding
transcription coactivator activity
transcription factor binding
basic helix-loop-helix transcription factor
regulation of transcription, DNA-templated
nervous system development
sensory organ development
response to glucose
dentate gyrus development
cerebellum development
neurogenesis
insulin secretion
endocrine pancreas development
positive regulation of insulin secretion
amacrine cell differentiation
enteroendocrine cell differentiation
glucose homeostasis
positive regulation of apoptotic process
positive regulation of cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
inner ear development
regulation of insulin secretion
regulation of intestinal epithelial structure maintenance
axon development
cellular response to glucocorticoid stimulus
negative regulation of type B pancreatic cell apoptotic process
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
transcription, DNA-templated
transcription from RNA polymerase II promoter
nucleocytoplasmic transport
nitric oxide mediated signal transduction
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
hindbrain development
response to drug
camera-type eye development
cell fate commitment
regulation of neuron differentiation
negative regulation of JAK-STAT cascade
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of cell cycle arrest
cellular response to glucose stimulus
positive regulation of transcription regulatory region DNA binding
multicellular organism development
cell differentiation
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