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Invitrogen
BRD9 Polyclonal Antibody
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FIGURE: 1 / 2
BRD9 Antibody (PA5-107081) in WB
Western Blot analysis of BRD9 in mouse and rat using a BRD9 Polyclonal Antibody (Product # PA5-107081) diluted 1:200. Lane 1: 60 µg mouse melanocytes (melba). Lane 2: 60 µg mouse melanoma (B16). Lane 3: 60 µg human melanocytes (HFSC). Lane 4: 60 µg human melanoma (SK-MEL5). Lane 5: 60 µg human melanoma (YUMAC). Lane 6: 60 µg rat Schwann cells. Secondary Antibody: Donkey anti-rabbit, diluted 1:2000. Image courtesy of Dr. Ivana de la Serna, University of Toledo.
Product Details
PA5-107081
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N terminal region of human BRD9
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%
Target Information
The BRD9 gene encodes a protein that is a crucial subunit of the SWI/SNF chromatin remodeling complex known as ncBAF (non-canonical BAF complex). As a bromodomain-containing protein, BRD9 acts as an 'epigenetic reader,' selectively recognizing acetyl-lysine marks on histones, which is essential for regulating chromatin structure and gene expression through the recruitment of acetylated transcriptional regulators. It has emerged as a significant player in epigenetic modulation and has been implicated in various cancers, such as cervical and non-small cell lung cancer, due to its over-expression. BRD9 is situated on the 5p arm of chromosome 5 and is a potential target for anticancer therapies, notably in acute myeloid leukemia (AML). Recent studies highlight the development of selective BRD9 inhibitors, indicating its potential for therapeutic targeting. Its role in cancer is linked to its function in transcriptional regulation and its involvement in the mammalian SWI/SNF complex, which is linked to tumor suppression mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bromodomain-containing protein 9; DKFZp434D0711; DKFZp686L0539; FLJ43530; Rhabdomyosarcoma antigen MU-RMS-40.8; sarcoma antigen NY-SAR-29; unnamed protein product
Gene Aliases: AL022779; BRD9; LAVS3040; PRO9856; SMARCI2; UNQ3040/PRO9856
UniProt ID: (Human) Q9H8M2, (Mouse) Q3UQU0
Entrez Gene ID: (Human) 65980, (Mouse) 105246
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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