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Invitrogen
Activin A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-109858
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 21-426 of human Inhibin beta A (INHBA) (NP_0021831)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.12 mg/mL
Amount
112 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPTPGSEGHS AAPDCPSCAL AALPKDVPNS QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Target Information
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A; Activin beta-A chain; EDF; Erythroid differentiation protein; Inhibin beta A chain
Gene Aliases: INHBA
UniProt ID: (Rat) P18331, (Mouse) Q04998
Entrez Gene ID: (Rat) 29200, (Mouse) 16323
G1/S transition of mitotic cell cycle
ovarian follicle development
mesoderm formation
hair follicle development
hematopoietic progenitor cell differentiation
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
negative regulation of cell proliferation
male gonad development
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of cell growth
positive regulation of cellular protein metabolic process
activin receptor signaling pathway
endodermal cell differentiation
growth
odontogenesis
response to drug
hemoglobin biosynthetic process
progesterone secretion
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of erythrocyte differentiation
negative regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of follicle-stimulating hormone secretion
mesodermal cell differentiation
cell development
palate development
positive regulation of ovulation
SMAD protein signal transduction
eyelid development in camera-type eye
cellular response to follicle-stimulating hormone stimulus
cellular response to cholesterol
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of hair follicle development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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