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          • Primary Antibodies ›
          • CRK Antibodies

          Invitrogen

          Crk Polyclonal Antibody

          View all (22) CRK antibodies

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          Cite Crk Polyclonal Antibody

          Additional Information:

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          • Antibody Testing Data (2)
          Crk Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Crk Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          Crk Antibody (PA5-112391) in ICC/IF

          Immunocytochemichal analysis of Crk in A549 cells using a Polyclonal antibody (Product # PA5-112391) at a dilution of 1:100. An Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibdoy was used. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          Crk Antibody in Immunocytochemistry (ICC/IF)
          Crk Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Crk Polyclonal Antibody

          Product Details

          PA5-112391

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:5,000
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant Human Adapter molecule crk protein (40-196AA)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          3 mg/mL

          Amount

          100 µg

          Purification

          Protein G

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.03% ProClin 300

          Storage conditions

          -20°C or -80°C if preferred

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2867126

          Target Information

          The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK-II; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX-interacting protein 2; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; proto-oncogene C-crk; reactive kinase; SAPK2a; CSAIDS binding protein 1; stress-activated protein kinase 2A; unnamed protein product; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_1; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_2; v-crk sarcoma virus CT10 oncogene-like protein

          View more View less

          Gene Aliases: CRK1; CRKII; Crko; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Hog; Mxi2; p38; p38ALPHA; p38Hog; PRKM14; PRKM15; RK; SAPK2A

          View more View less

          UniProt ID: (Human) P46108, (Rat) Q63768, (Human) Q16539

          View more View less

          Entrez Gene ID: (Human) 1398, (Rat) 54245, (Human) 1432, (Rat) 81649

          View more View less

          Function(s)
          phosphotyrosine binding insulin-like growth factor receptor binding protein binding cytoskeletal protein binding SH3 domain binding enzyme binding kinase binding protein domain specific binding receptor signaling complex scaffold activity protein binding, bridging receptor tyrosine kinase binding ubiquitin protein ligase binding signaling adaptor activity SH2 domain binding protein phosphorylated amino acid binding scaffold protein binding protein tyrosine kinase binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity ATP binding protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein serine kinase activity kinase activity
          Process(es)
          MAPK cascade negative regulation of inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway positive regulation of gene expression positive regulation of myotube differentiation platelet activation osteoclast differentiation stress-activated protein kinase signaling cascade positive regulation of cyclase activity positive regulation of interleukin-12 production negative regulation of hippo signaling intracellular signal transduction cellular response to vascular endothelial growth factor stimulus p38MAPK cascade signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation vascular endothelial growth factor receptor signaling pathway positive regulation of muscle cell differentiation stress-activated MAPK cascade 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to ionizing radiation cellular response to UV-B cellular senescence stress-induced premature senescence cellular response to virus regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion positive regulation of reactive oxygen species metabolic process response to yeast cell adhesion enzyme linked receptor protein signaling pathway cell proliferation regulation of cell shape regulation of signal transduction positive regulation of smooth muscle cell migration cell migration actin cytoskeleton organization positive regulation of cell growth regulation of actin cytoskeleton organization regulation of Rac protein signal transduction positive regulation of Rac protein signal transduction response to hepatocyte growth factor response to hydrogen peroxide negative regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade ephrin receptor signaling pathway regulation of wound healing negative regulation of wound healing response to cholecystokinin cellular response to transforming growth factor beta stimulus cellular response to nitric oxide protein localization to membrane postsynaptic specialization assembly positive regulation of substrate adhesion-dependent cell spreading response to peptide regulation of intracellular signal transduction cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus cellular response to endothelin regulation of cell motility negative regulation of cell motility neuron migration regulation of immune system process regulation of leukocyte migration lipid metabolic process dendrite development hippocampus development cerebral cortex development establishment of cell polarity regulation of cell migration regulation of cell adhesion mediated by integrin helper T cell diapedesis reelin-mediated signaling pathway regulation of dendrite development cell chemotaxis activation of GTPase activity cerebellar neuron development positive regulation of intracellular signal transduction regulation of T cell migration DNA damage checkpoint cell morphogenesis cartilage condensation angiogenesis osteoblast differentiation placenta development response to dietary excess chondrocyte differentiation glucose metabolic process regulation of transcription, DNA-templated protein phosphorylation cellular response to DNA damage stimulus transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development response to glucose myoblast differentiation involved in skeletal muscle regeneration phosphorylation peptidyl-serine phosphorylation fatty acid oxidation regulation of ossification lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide response to insulin tumor necrosis factor-mediated signaling pathway response to muscle stretch positive regulation of protein import into nucleus positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import protein autophosphorylation striated muscle cell differentiation positive regulation of cardiac muscle cell proliferation bone development cellular response to tumor necrosis factor negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation regulation of synaptic membrane adhesion cellular response to acetaldehyde
          It has to be done as per old AB suggested Products section.

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