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Invitrogen
H-cadherin Polyclonal Antibody
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H-cadherin Antibody (PA5-114998) in IHC (P)
Immunohistochemistry analysis of H-cadherin in human kidney tissue sections. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114998) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-114998
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDH13(Accession P55290), corresponding to amino acid residues P144-T194.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CDH13.
靶标信息
The protein encoded by this gene has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAD13; Cadherin-13; CD39 antigen-like 3; CD39-like 3; CD39L3; ecto-apyrase 3; ecto-ATPase 3; ecto-ATPDase 3; H-cadherin; HB6; Heart cadherin; heart-cadherin; NTPDase 3; NTPDase-3; P105; T cad; T Cadherin; T-cad; Truncated cadherin; truncated-cadherin
基因别名: 4932416G01Rik; CDH13; CDHH; Cdht; T-cadherin; Tcad
UniProt ID: (Mouse) Q9WTR5
Entrez Gene ID: (Mouse) 12554
regulation of cell growth
positive regulation of endothelial cell proliferation
positive regulation of cell-matrix adhesion
sprouting angiogenesis
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
Rho protein signal transduction
negative regulation of cell proliferation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Rac protein signal transduction
lamellipodium assembly
regulation of endocytosis
positive regulation of cell migration
regulation of epidermal growth factor receptor signaling pathway
endothelial cell migration
keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
localization within membrane
low-density lipoprotein particle mediated signaling
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