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Invitrogen
HP1 gamma Polyclonal Antibody
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FIGURE: 1 / 3
HP1 gamma Antibody (PA5-115379) in ICC/IF
Immunocytochemistry analysis of HP1 gamma in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115379). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) an... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115379
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CBX3(Accession Q13185), corresponding to amino acid residues F54-S104.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HP1 gamma.
Target Information
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromobox homolog 3 (HP1 gamma homolog, Drosophila); hech; heterochromatin protein 1 gamma; heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HGNC:1553; HP1 gamma; HP1 gamma homolog; HPy; modifier 2 protein; OTTHUMP00000202463; unnamed protein product
Gene Aliases: HECH; HP1-GAMMA; HP1g; HP1gamma; HP1Hs-gamma; M32
UniProt ID: (Human) Q13185
Entrez Gene ID: (Human) 11335, (Rat) 297093, (Mouse) 12417
transcription cofactor binding
chromatin binding
protein binding
enzyme binding
protein domain specific binding
identical protein binding
histone H3K9me2/3 reader activity
histone H1K26me1 reader activity
histone H1K26me2 reader activity
histone methyltransferase binding
transcription regulatory region sequence-specific DNA binding
DNA-binding transcription factor binding
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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