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Invitrogen
Synaptotagmin 1/2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SYT1(Accession P21579), corresponding to amino acid residues G176-V226.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Synaptotagmin 1/2.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ42519; inositol polyphosphate-binding protein; IP4-binding protein; p65; synaptotagmin I; synaptotagmin II; sytI; sytII; unnamed protein product
Gene Aliases: BAGOS; CMS7; CMS7A; CMS7B; G630098F17Rik; IP4BP; mKIAA4194; MYSPC; P65; RATSYNII; SVP65; SYNII; SYT; SytI; SytII
UniProt ID: (Human) P21579, (Human) Q8N9I0, (Rat) P21707, (Mouse) P46096, (Mouse) P46097, (Rat) P29101
Entrez Gene ID: (Human) 6857, (Human) 127833, (Rat) 25716, (Mouse) 20979, (Mouse) 20980, (Rat) 24805
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
phospholipid binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
syntaxin-1 binding
clathrin binding
identical protein binding
protein heterodimerization activity
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
calcium ion sensor activity
molecular condensate scaffold activity
inositol 1,3,4,5 tetrakisphosphate binding
syntaxin binding
syntaxin-3 binding
vesicle-mediated transport
regulation of calcium ion-dependent exocytosis
calcium-dependent activation of synaptic vesicle fusion
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
detection of calcium ion
drug transmembrane transport
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
regulation of dopamine secretion
vesicle organization
regulation of exocytosis
regulation of endocytosis
regulation of vesicle fusion
positive regulation of vesicle fusion
positive regulation of dopamine secretion
synaptic vesicle recycling
positive regulation of calcium ion-dependent exocytosis
negative regulation of neurotransmitter secretion
positive regulation of synaptic transmission
protein insertion into membrane
protein heterooligomerization
response to calcium ion
regulation of synaptic transmission, glutamatergic
inhibitory postsynaptic potential
calcium activated phospholipid scrambling
cellular response to calcium ion
fast, calcium ion-dependent exocytosis of neurotransmitter
membraneless organelle assembly
regulation of calcium-dependent activation of synaptic vesicle fusion
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
synaptic vesicle exocytosis
calcium ion regulated exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
regulated exocytosis
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
synchronous neurotransmitter secretion
synaptic vesicle cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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