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Invitrogen
VHL Polyclonal Antibody
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VHL Antibody (PA5-116114) in WB
Western blot was performed using VHL Polyclonal Antibody (Product # PA5-116114) and a 19 kDa band corresponding to VHL was observed. Whole cell extracts (30 µg lysate) of Raji (Lane 1), Jurkat (Lane 2), ACHN (Lane 3), 786-O (Lane 4) and 769-P (Lane 5) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX), 12 well. Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000) an... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-116114
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human VHL(Accession P40337), corresponding to amino acid residues E42-D92.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total VHL.
靶标信息
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein G7; pVHL; VHL19; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog
基因别名: VHL; Vhlh
UniProt ID: (Mouse) P40338, (Rat) Q64259
Entrez Gene ID: (Mouse) 22346, (Rat) 24874
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
response to hypoxia
type B pancreatic cell differentiation
pancreatic A cell differentiation
regulation of transcription, DNA-templated
NLS-bearing protein import into nucleus
proteasomal protein catabolic process
protein transport
protein ubiquitination
protein catabolic process
neuron differentiation
extracellular matrix organization
regulation of catecholamine metabolic process
blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
protein heterooligomerization
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of thymocyte apoptotic process
negative regulation of thymocyte apoptotic process
negative regulation of hypoxia-inducible factor-1alpha signaling pathway
regulation of apoptotic signaling pathway
response to ethanol
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