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Invitrogen
Viperin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-117125
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
3.28 mg/mL
Amount
328 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: PC-3, Mouse spleen, Rat lung, Rat spleen, Rat kidney
Immunogen sequence: EKINFSGGEP FLQDRGEYLG KLVRFCKVEL RLPSVSIVSN GSLIRERWFQ NYGEYLDILA ISCDSFDEEV NVLIGRGQGK KNHVENLQKL RRWCRDYRVA FKINSVINRF NVEEDMTEQI KALNPVRWKV FQCLLIEGEN CGEDALREAE RFVIGDEEFE RFLERHKEVS CLVPESNQKM KDSYLILDEY MRFLNCRKGR KDPSKSILDV GVEEAIKFSG FDEKMFLKRG GKYIWSKADL KLDW
Target Information
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bone-expressed sequence tag 5 protein; CIG5; cytomegalovirus-induced gene 5 protein; radical S-adenosyl methionine domain-containing protein 2; Rsad2; unnamed protein product; VHSV-induced-like protein; vig-1; viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Aliases: 2510004L01Rik; Best5; cig33; cig5; SAND; Vig1
UniProt ID: (Human) Q8WXG1, (Rat) O70600, (Mouse) Q8CBB9
Entrez Gene ID: (Human) 91543, (Rat) 65190, (Mouse) 58185
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
negative regulation of viral genome replication
negative regulation of protein secretion
positive regulation of immune response
defense response to virus
positive regulation of T-helper 2 cell cytokine production
ossification
regulation of ossification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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