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Invitrogen
MINA53 Polyclonal Antibody
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FIGURE: 1 / 6
MINA53 Antibody (PA5-118242) in ICC/IF
Immunofluorescence staining of MINA in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with MINA53 Polyclonal Antibody (Product # PA5-118242, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-118242
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human MINA/MINA53/RIOX2 fragment
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60S ribosomal protein L27a histidine hydroxylase; bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; histone lysine demethylase MINA; MDIG2; cell cycle regulatory protein; mineral dust induced gene; mineral dust induced gene protein; mineral dust-induced gene; mineral dust-induced protein; mina53; nucleolar protein; NO52; ribosomal oxygenase 2; RIOX2; JMJD10; MYC induced nuclear antigen; MYC-induced nuclear antigen 53; myc-induced nuclear antigen, 53 kDa; nucleolar protein 52; Protein mina53; ribosomal oxygenase MINA; unnamed protein product
Gene Aliases: JMJD10; MDIG; MINA; MINA53; NO52; ROX
UniProt ID: (Human) Q8IUF8
Entrez Gene ID: (Human) 84864
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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