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Invitrogen
HLA-DRA Polyclonal Antibody
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HLA-DRA Antibody (PA5-119196) in WB
Western blot analysis of MHC II HLA-DR in Lane 1: Wild-type Jurkat cell lysate; Lane 2: MHCDRa knockout Jurkat cell lysate . Samples were incubated with polyclonal antibody (Product # PA5-119196) at a dilution of 3 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-119196
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein HLA Class II Histocompatibility Antigen, DR Alpha Chain. The antigen corresponds to amino acid range 27-216 of the target protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA
基因别名: HLA-DRA; HLA-DRA1
Entrez Gene ID: (Human) 3122
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