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Invitrogen

WNK1 Polyclonal Antibody

View all (17) WNK1 antibodies

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WNK1 Polyclonal Antibody

Product Details

PA5-120255

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human WNK1 (NP_055638.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Amount

44 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913827

Product Specific Information

Positive test controls include: Mouse liver, Rat liver. The target is usually found in the following locations: Cytoplasm.

Immunogen sequence: MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ QDDIEELETK

Target Information

WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: long kinase transcript; MGC163339; MGC163341; protein kinase lysine-deficient 1; protein kinase with no lysine 1; unnamed protein product; With no K; WNK1

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Gene Aliases: 6430573H23Rik; EG406236; Hsn2; mKIAA0344; Prkwnk1

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UniProt ID: (Mouse) P83741, (Rat) Q9JIH7

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Entrez Gene ID: (Mouse) 232341, (Rat) 116477

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding potassium channel inhibitor activity protein kinase binding phosphatase binding protein serine/threonine kinase inhibitor activity protein kinase activator activity protein serine kinase activity molecular condensate scaffold activity
Process(es)
regulation of sodium ion transport positive regulation of systemic arterial blood pressure protein phosphorylation ion transport cell volume homeostasis signal transduction heart development regulation of blood pressure negative regulation of autophagy negative regulation of sodium ion transport regulation of mRNA export from nucleus positive regulation of T cell chemotaxis negative regulation of protein ubiquitination negative regulation of cell-cell adhesion mediated by integrin negative regulation of kinase activity negative regulation of heterotypic cell-cell adhesion intracellular signal transduction sodium ion transmembrane transport chemokine (C-C motif) ligand 21 signaling pathway protein insertion into ER membrane by stop-transfer membrane-anchor sequence positive regulation of angiogenesis protein autophosphorylation ion homeostasis modulation of synaptic transmission T cell receptor signaling pathway negative regulation of small GTPase mediated signal transduction potassium ion homeostasis cation homeostasis cellular response to calcium ion cellular hyperosmotic response potassium ion transmembrane transport negative regulation of pancreatic juice secretion positive regulation of canonical Wnt signaling pathway lymphocyte migration into lymph node membraneless organelle assembly regulation of sodium ion transmembrane transport negative regulation of leukocyte cell-cell adhesion negative regulation of protein localization to plasma membrane positive regulation of potassium ion import positive regulation of mitotic cytokinesis regulation of cation transmembrane transport positive regulation of termination of RNA polymerase II transcription cellular response to chemokine
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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