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Invitrogen
TET1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120326
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.20 mg/mL
Amount
120 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Neuro-2a, Rat heart. The target is usually found in the following locations: Nucleus.
Immunogen sequence: TLGSNTETVQ PEVKSETEPH FILKSSDNTK TYSLMPSAPH PVKEASPGFS WSPKTASATP APLKNDATAS CGFSERSSTP HCTMPSGRLS GANAAAADGP G
Target Information
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; LCX; leukemia-associated protein with a CXXC domain; RP11-119F7.1; ten-eleven translocation 1 gene protein; ten-eleven translocation 1 gene protein homolog; ten-eleven translocation 1 protein; ten-eleven translocation-1; tet oncogene 1; unnamed protein product
Gene Aliases: 2510010B09Rik; bA119F7.1; CXXC6; D10Ertd17e; LCX; mKIAA1676
UniProt ID: (Human) Q8NFU7, (Mouse) Q3URK3
Entrez Gene ID: (Human) 80312, (Rat) 309902, (Mouse) 52463
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
iron ion binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
methylcytosine dioxygenase activity
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell differentiation
chromatin remodeling
protein O-linked glycosylation
regulation of gene expression
stem cell population maintenance
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
regulation of gene expression, epigenetic
hypomethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
biological_process
DNA demethylation of male pronucleus
dendrite morphogenesis
chromosomal 5-methylcytosine DNA demethylation pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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