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Invitrogen
Desmoglein 1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-121240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 800-1049 of human DSG1 (NP_001933.2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.67 mg/mL
Amount
67 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: A-431, HeLa, 293T, BT-474. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Immunogen sequence: SPHFGTTTVI SESTYPSGPG VLHPKPILDP LGYGNVTVTE SYTTSDTLKP SVHVHDNRPA SNVVVTERVV GPISGADLHG MLEMPDLRDG SNVIVTERVI APSSSLPTSL TIHHPRESSN VVVTERVIQP TSGMIGSLSM HPELANAHNV IVTERVVSGA GVTGISGTTG ISGGIGSSGL VGTSMGAGSG ALSGAGISGG GIGLSSLGGT ASIGHMRSSS DHHFNQTIGS ASPSTARSRI TKYSTVQYSK
Target Information
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cadherin family member 4; desmoglein 1 beta; desmoglein 1 gamma; desmosomal glycoprotein; desmosomal glycoprotein 1; pemphigus foliaceus antigen; unnamed protein product
Gene Aliases: CDHF4; DG1; DSG; Dsg1b; Dsg1c; EPKHE; EPKHIA; PPKS1; SPPK1
UniProt ID: (Human) Q02413
Entrez Gene ID: (Human) 1828, (Rat) 291755
inflammatory response
cell-cell junction assembly
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
response to progesterone
positive regulation of epidermal cell differentiation
positive regulation of keratinocyte differentiation
protein stabilization
maternal process involved in female pregnancy
establishment of skin barrier
cellular response to UV-B
epithelial cell-cell adhesion
cell-cell adhesion
positive regulation of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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