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Invitrogen
Phospho-c-Cbl (Tyr700) Polyclonal Antibody
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Phospho-c-Cbl (Tyr700) Antibody (PA5-121300) in WB
Western blot analysis of Phospho-c-Cbl (Tyr700) in extracts of Jurkat cells. Samples were incubated with Phospho-c-Cbl (Tyr700) Polyclonal antibody (Product # PA5-121300) using a dilution of 1:2,000 or CBL antibody (Product # PA5-87495). Followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Jurkat cells were treated by Pervanadate (1 mM) at 37°C for 30 minutes. Lysates/pro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-121300
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around Y700 of human CBL (NP_005179.2).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.09 mg/mL
规格
9 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: Jurkat. The target is usually found in the following locations: Cell membrane, Cytoplasm.
Immunogen sequence: TEYMT
靶标信息
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Casitas B-lineage lymphoma proto-oncogene; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
基因别名: CBL; CBL2; RNF55
Entrez Gene ID: (Human) 867
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