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Invitrogen

Phospho-NMDAR1 (Ser896, Ser897) Polyclonal Antibody

View all (36) NMDAR1 antibodies

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Phospho-NMDAR1 (Ser896, Ser897) Polyclonal Antibody

Product Details

PA5-121322

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S896 & S897 of human NMDAR1 (NP_015566.1).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.67 mg/mL

Amount

67 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914894

Product Specific Information

Positive test controls include: HeLa. The target is usually found in the following locations: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, postsynaptic density, synapse.

Immunogen sequence: RRSSKD

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Glun1r; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; putative NMDtranscript(altAcc_e2); RP11-350O14.1; unnamed protein product

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Gene Aliases: DEE101; GluN1; GluRdelta1; GluRzeta1; hNR1; M100174; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding ligand-gated ion channel activity ligand-gated sodium channel activity glycine binding glutamate binding transmitter-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity macromolecular complex binding glycine-gated cation channel activity ionotropic glutamate receptor activity receptor binding cation channel activity enzyme binding phosphatase binding voltage-gated cation channel activity glutamate receptor binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor binding
Process(es)
ion transport cation transport chemical synaptic transmission brain development visual learning positive regulation of calcium ion transport into cytosol propylene metabolic process calcium-mediated signaling ionotropic glutamate receptor signaling pathway sodium ion transmembrane transport regulation of membrane potential response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity protein heterotetramerization positive regulation of synaptic transmission, glutamatergic calcium ion homeostasis excitatory postsynaptic potential calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission positive regulation of reactive oxygen species biosynthetic process regulation of cation transmembrane transport cellular response to beta-amyloid response to glycine positive regulation of excitatory postsynaptic potential conditioned taste aversion response to hypoxia startle response suckling behavior response to amphetamine calcium ion transport cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning regulation of cell communication response to amine sensory perception of pain pons maturation hypothalamus development cerebral cortex development social behavior synaptic transmission, glutamatergic positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange regulation of long-term neuronal synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis regulation of synapse organization neuromuscular process positive regulation of mitochondrial calcium ion concentration response to calcium ion regulation of synapse assembly regulation of postsynaptic membrane potential prepulse inhibition male mating behavior response to fungicide protein-containing complex assembly cellular response to manganese ion regulation of presynaptic membrane potential chemical synaptic transmission, postsynaptic regulation of plasma membrane bounded cell projection organization positive regulation of Schwann cell migration positive regulation of dendritic spine maintenance response to glycoside protein localization to postsynaptic membrane cellular response to glycine rhythmic process
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