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Invitrogen

Phospho-Beclin 1 (Ser15) Polyclonal Antibody

View all (41) Beclin 1 antibodies

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Phospho-Beclin 1 (Ser15) Polyclonal Antibody

Product Details

PA5-121357

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S15 of human Beclin 1 (NP_003757.1).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.93 mg/mL

Amount

93 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914929

Product Specific Information

Positive test controls include: NIH/3T3, C6. The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane.

Immunogen sequence: QVSFV

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1-beta; beclin1-gamma; BECN; coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; partial ORF; putative; testis secretory sperm-binding protein Li 215e; unnamed protein product

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Gene Aliases: ATG6; Beclin1; VPS30

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UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597

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Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208

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Function(s)
protein binding protein kinase binding protein binding, bridging ubiquitin protein ligase binding identical protein binding phosphatidylinositol 3-kinase binding GTPase binding binding, bridging
Process(es)
autophagosome assembly mitophagy response to hypoxia cytoplasmic pattern recognition receptor signaling pathway autophagy cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression JNK cascade circadian rhythm negative regulation of cell proliferation protein secretion response to xenobiotic stimulus response to iron(II) ion response to lead ion regulation of autophagy negative regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy macroautophagy regulation of macroautophagy response to nutrient levels regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to amino acid starvation phosphatidylinositol-3-phosphate biosynthetic process p38MAPK cascade cellular response to glucose starvation negative regulation of apoptotic process negative regulation of programmed cell death engulfment of apoptotic cell early endosome to late endosome transport late endosome to vacuole transport neuron development beta-amyloid metabolic process regulation of catalytic activity response to other organism bone development SMAD protein signal transduction positive regulation of stress granule assembly protein-containing complex assembly cellular response to hydrogen peroxide cellular response to aluminum ion cellular response to copper ion cellular response to epidermal growth factor stimulus cellular response to oxygen-glucose deprivation autophagosome maturation response to mitochondrial depolarisation positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of autophagosome assembly negative regulation of lysosome organization positive regulation of autophagosome assembly positive regulation of intrinsic apoptotic signaling pathway protein targeting to lysosome cellular defense response positive regulation of protein kinase B signaling angiogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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