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Invitrogen
GREM1 Polyclonal Antibody
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FIGURE: 1 / 5
GREM1 Antibody (PA5-121945) in IHC (P)
Immunohistochemistry (Paraffin) analysis of GREM1 in mouse stomach tissue using GREM1 Polyclonal Antibody (Product # PA5-119163) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-121945
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Gremlin 1. The antigen corresponds to amino acid range 25-184 of the target protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP antagonist; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; unnamed protein product
Gene Aliases: Cktsf1b1; Drm; Grem; ld
UniProt ID: (Mouse) O70326
Entrez Gene ID: (Mouse) 23892
cell morphogenesis
angiogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of leukocyte chemotaxis
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
proximal/distal pattern formation
regulation of signal transduction
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
negative regulation of apoptotic process
endothelial cell migration
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
regulation of focal adhesion assembly
cardiac muscle cell differentiation
limb development
cardiac muscle cell myoblast differentiation
negative regulation of SMAD protein import into nucleus
ureteric bud formation
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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