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Invitrogen
LRP5 Polyclonal Antibody
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FIGURE: 1 / 1
LRP5 Antibody (PA5-13144) in IHC (P)
Immunohistochemistry analysis of LRP5 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with LRP5 polyclonal antibody (Product # PA5-13144) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-13144
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1538-1567 amino acids from the C-terminal region of human LRP5
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:6697; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7
Gene Aliases: BMND1; HBM; LR3; LRP5; LRP7; mKIAA4142; OPPG
UniProt ID: (Mouse) Q91VN0
Entrez Gene ID: (Mouse) 16973
gastrulation with mouth forming second
vasculature development
positive regulation of mesenchymal cell proliferation
osteoblast development
glucose catabolic process
endocytosis
multicellular organism development
cholesterol metabolic process
regulation of blood pressure
positive regulation of cell proliferation
anterior/posterior pattern specification
Wnt signaling pathway
positive regulation of osteoblast proliferation
somatic stem cell population maintenance
limb morphogenesis
extracellular matrix-cell signaling
cell migration involved in gastrulation
cholesterol homeostasis
embryonic digit morphogenesis
regulation of apoptotic process
Wnt signaling pathway involved in dorsal/ventral axis specification
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
bone remodeling
regulation of bone remodeling
bone marrow development
positive regulation of sequence-specific DNA binding transcription factor activity
anatomical structure regression
retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
bone development
bone morphogenesis
branching involved in mammary gland duct morphogenesis
mammary gland duct morphogenesis
adipose tissue development
cell-cell signaling involved in mammary gland development
regulation of canonical Wnt signaling pathway
regulation of insulin secretion involved in cellular response to glucose stimulus
retina vasculature morphogenesis in camera-type eye
retinal blood vessel morphogenesis
negative regulation of protein serine/threonine kinase activity
apoptotic process involved in patterning of blood vessels
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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