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Invitrogen
BRG1 Polyclonal Antibody
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FIGURE: 1 / 4
BRG1 Antibody (PA5-141072) in IHC (P)
Immunohistochemistry analysis of BRG1 in paraffin-embedded human lung carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with BRG1 Polyclonal antibody (Product # PA5-141072) using a dilution of 1:400 for 30 minu... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-141072
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human BRG1 aa 200-300/1647.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; BRG1-associated factor 190A; FLJ39786; Mitotic growth and transcription activator; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1
Gene Aliases: b2b508.1Clo; b2b692Clo; BAF190A; BRG1; HP1-BP72; SMARCA4; SNF2B; SNF2beta; SNF2L4; SW1/SNF
UniProt ID: (Mouse) Q3TKT4
Entrez Gene ID: (Mouse) 20586
nucleotide binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
Tat protein binding
nucleosomal DNA binding
protein complex binding
histone binding
protein N-terminus binding
androgen receptor binding
DNA polymerase binding
lysine-acetylated histone binding
DNA helicase
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
nucleosome assembly
nucleosome disassembly
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
glial cell fate determination
heart development
positive regulation of cell proliferation
DNA methylation on cytosine within a CG sequence
chromatin modification
stem cell population maintenance
neurogenesis
positive regulation of Wnt signaling pathway
extracellular matrix organization
keratinocyte differentiation
negative regulation of cell growth
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation by host of viral transcription
histone H3 acetylation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
epidermis morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
definitive erythrocyte differentiation
heart trabecula formation
negative regulation of androgen receptor signaling pathway
pharyngeal arch artery morphogenesis
lens fiber cell development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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