Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • PCR Equipment and Supplies
    • Chromatography Columns and Cartridges
    • Lab Centrifuges
    • Molecular Biology Reagents and Kits
    • Lab Plasticware and Supplies
    • See all product categories
  • Applications
    • Chromatography
    • Cell Culture
    • Real-Time PCR
    • Mass Spectrometry
    • Lab Plasticware and Supplies
    • Electron Microscopy
    • Protein Biology
    • PCR
    • RNAi
    • Environmental
    • See all applications and techniques
  • Services
    • Custom Services
    • Enterprise-Level Lab Informatics
    • Financial and Leasing Services
    • Instrument Services
    • OEM and Commercial Supply
    • Training Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • Learning Centers
    • Contact Us
    • Change Location
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Antibody Therapy Solution
    • Cell and Gene Therapy Solution
    • Academic
    • Industrial and Applied Sciences
  • New Products
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Contact Us
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Membership
            • AR Statement & Invoice Inquiry
            • Custom Products & Projects
          • Primary Antibodies ›
          • TGF beta-1 Antibodies

          Invitrogen

          TGF beta-1 Polyclonal Antibody

          View all (48) TGF beta-1 antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support

          Cite TGF beta-1 Polyclonal Antibody

          {{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

          {{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
          • Antibody Testing Data (4)
          TGF beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          TGF beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          TGF beta-1 Antibody (PA5-145252) in IHC (P)

          Immunohistochemistry (Paraffin) analysis of TGF beta-1 in porcine lymph node tissue using TGF beta-1 Polyclonal Antibody (Product # PA5-145251) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          TGF beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-1 Antibody in Western Blot (WB)
          TGF beta-1 Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          TGF beta-1 Polyclonal Antibody

          Product Details

          PA5-145252

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.01-2 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          5-20 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Pig

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant Pig TGFb1 protein, Ala279-Ser390 (Accession #P07200)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Amount

          10 µg

          Purification

          Antigen affinity chromatography, Protein A

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.05% Proclin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3093599

          Target Information

          TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: cytokine; latency-associated peptide; prepro-transforming growth factor beta-1; TGF b; TGF b 1; TGF beta; tgf beta 1; TGF beta-1; TGF beta-1 protein; tgf beta1; TGF β; TGF β 1; TGF β1; TGF-B1; TGF-beta 1 protein; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; Transforming growth factor beta-1; transforming growth factor beta1; transforming growth factor β1; transforming growth factor, beta 1 (Camurati-Engelmann disease); unnamed protein product

          View more View less

          Gene Aliases: CAEND1; CED; DPD1; IBDIMDE; LAP; TGF-BETA-1; TGF-beta1; TGFB; TGFbeta

          View more View less

          UniProt ID: (Human) P01137, (Pig) P07200

          View more View less

          Entrez Gene ID: (Human) 7040, (Pig) 397078

          View more View less

          Function(s)
          type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding protein serine/threonine kinase activator activity macromolecular complex binding antigen binding growth factor
          Process(es)
          vasculogenesis ureteric bud development response to hypoxia morphogenesis of a branching structure epithelial to mesenchymal transition neural tube closure sprouting angiogenesis chondrocyte differentiation hematopoietic progenitor cell differentiation connective tissue replacement involved in inflammatory response wound healing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target heart valve morphogenesis aortic valve morphogenesis protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process apoptotic process transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling negative regulation of neuroblast proliferation salivary gland morphogenesis heart development female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to wounding response to glucose response to gamma radiation positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression negative regulation of extracellular matrix disassembly positive regulation of epithelial to mesenchymal transition macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of macrophage cytokine production oligodendrocyte development positive regulation of microglia differentiation regulation of striated muscle tissue development neural tube development cell differentiation hyaluronan catabolic process negative regulation of cell growth regulation of cell migration positive regulation of cell migration organ regeneration membrane protein intracellular domain proteolysis positive regulation of protein complex assembly positive regulation of exit from mitosis response to estradiol response to progesterone regulation of interleukin-23 production negative regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production receptor catabolic process positive regulation of superoxide anion generation positive regulation of collagen biosynthetic process response to vitamin D negative regulation of MyD88-dependent toll-like receptor signaling pathway response to laminar fluid shear stress response to immobilization stress cellular response to platelet-derived growth factor stimulus myofibroblast differentiation regulation of cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth myelination positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration regulatory T cell differentiation cell-cell junction organization response to ethanol positive regulation of regulatory T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermal growth factor receptor signaling pathway negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation inner ear development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of inflammatory response negative regulation of phagocytosis defense response to fungus positive regulation of chemotaxis positive regulation of cellular component organization positive regulation of multicellular organismal process positive regulation of protein metabolic process negative regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling ventricular cardiac muscle tissue morphogenesis regulation of blood vessel remodeling face morphogenesis frontal suture morphogenesis positive regulation of SMAD protein import into nucleus negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus positive regulation of mononuclear cell migration odontoblast differentiation extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway liver regeneration cellular response to virus transforming growth factor beta receptor superfamily signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of extracellular matrix assembly response to salt positive regulation of mesenchymal stem cell proliferation regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane positive regulation of vasculature development positive regulation of STAT cascade regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cellular response to acetaldehyde cellular response to insulin-like growth factor stimulus embryonic liver development negative regulation of cell-cell adhesion mediated by cadherin positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of endothelial cell apoptotic process positive regulation of primary miRNA processing positive regulation of cardiac muscle cell differentiation negative regulation of transcription from RNA polymerase II promoter MAPK cascade negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of sodium ion transport tolerance induction to self antigen protein phosphorylation cellular calcium ion homeostasis inflammatory response cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly Notch signaling pathway endoderm development germ cell migration positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation cell migration regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell-cell adhesion negative regulation of ossification osteoclast differentiation positive regulation of bone mineralization positive regulation of histone deacetylation lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process mononuclear cell proliferation positive regulation of peptidyl-serine phosphorylation positive regulation of histone acetylation positive regulation of protein dephosphorylation negative regulation of T cell proliferation positive regulation of odontogenesis myeloid dendritic cell differentiation T cell homeostasis positive regulation of MAP kinase activity protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling negative regulation of cytolysis negative regulation of mitotic cell cycle muscle cell cellular homeostasis positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of binding regulation of DNA binding positive regulation of cell division pathway-restricted SMAD protein phosphorylation regulation of SMAD protein import into nucleus mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis regulation of cartilage development lens fiber cell differentiation positive regulation of cell cycle arrest cellular response to organic cyclic compound positive regulation of NAD+ ADP-ribosyltransferase activity negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor clustering transforming growth factor beta receptor signaling pathway involved in heart development regulation of actin cytoskeleton reorganization positive regulation of transcription regulatory region DNA binding
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us - 400 820 8982
          • Instrument Quotation
          • Technical Support Centers
          • Documents and Certificates
          • Channel Partner Authorization
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Notice
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          China flag icon
          China
          本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。
          经营证照公示 | ICP备案号:沪ICP备11003924号 | 沪公网安备 31011502006935号

          Your items have has been added!


          Host server : magellan-search-blue-7fb9f846c9-wx6nt:80/100.66.72.150:80.
          git-commit: 8207b5afa5c305bd40e0a4f0b9b53fd46f2a8829
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.59.1-2026.09.91-1.0