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Invitrogen
PMCA2 ATPase Polyclonal Antibody
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PMCA2 ATPase Antibody (PA5149905) in IHC (P)
Immunohistochemistry analysis of PMCA2 ATPase in paraffin-embedded Mouse Cerebrum tissue. Samples were incubated with PMCA2 ATPase Polyclonal (Product # PA5149905) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5149905
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant ATPase, Ca++ Transporting, Plasma Membrane 2 (ATP2B2) (Ala417-Ile830)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; deaf waddler; plasma membrane Ca++-ATPase; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; wriggle
基因别名: ATP2B2; D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy; wms; wri
UniProt ID: (Rat) P11506, (Mouse) Q9R0K7
Entrez Gene ID: (Rat) 24215, (Mouse) 11941
calcium-transporting ATPase activity
calcium ion binding
calmodulin binding
ATP binding
protein C-terminus binding
PDZ domain binding
calcium-dependent ATPase activity
acetylcholine receptor binding
glutamate receptor binding
metal ion binding
nucleotide binding
hydrolase activity
primary active transporter
cell morphogenesis
neural retina development
calcium ion transport
cellular calcium ion homeostasis
organelle organization
brain development
lactation
sensory perception of sound
locomotory behavior
metabolic process
regulation of cell size
cerebellum development
cerebellar Purkinje cell layer morphogenesis
cerebellar Purkinje cell differentiation
cerebellar granule cell differentiation
neuron differentiation
locomotion
serotonin metabolic process
inner ear morphogenesis
otolith mineralization
cGMP metabolic process
regulation of synaptic plasticity
inner ear development
synapse organization
neuromuscular process controlling balance
detection of mechanical stimulus involved in sensory perception of sound
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
auditory receptor cell stereocilium organization
inner ear receptor cell differentiation
calcium ion transmembrane transport
cochlea development
calcium ion export
transport
ion transport
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