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Invitrogen
alpha-1 Antitrypsin Polyclonal Antibody
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图: 1 / 9
alpha-1 Antitrypsin Antibody (PA5-16661) in ICC/IF
Immunofluorescent analysis of Alpha-1-Antitrypsin was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Alpha-1-Antitrypsin Rabbit Polyclonal Antibody (Product # PA5-16661) at 1:250 dilution in 0.1% BSA and... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-16661
应用
建议稀释比
已发表文章
产品规格
种属反应
Horse,
Human,
Mink,
Non-human primate
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Purified human serum alpha-1-AT
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
purified
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA5-16661 targets Alpha-1-Antitrypsin in IHC (P) applications and shows reactivity with Equine, Human, Mink, monkey, and baboon samples. Does not react with Canine, Chicken, Feline, Guinea Pig, Goat, Marsupial, mouse, Ovine, and Porcine samples
The PA5-16661 immunogen is purified human serum alpha-1-AT.
靶标信息
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: a-1 AT; a1-antitrypsin; alpha 1 antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; Digestive Zymogen; MGC23330; MGC9222; Protease Serine 1; Serine Protease 1; Serpin A1; TRP1; TRY1
基因别名: AAT; PI; PRO0684; PRO2209; SERPINA1
Entrez Gene ID: (Human) 5265
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