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Invitrogen
GluR2/GluR3/GluR4 Polyclonal Antibody
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GluR2/GluR3/GluR4 Antibody (PA5-17314) in WB
Western blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Brain (Lane 1), Rat Brain (Lane 2), Mouse Lung (Lane 3), Mouse Kidney (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Lung (Lane 6) and Rat Kidney (Lane 7). The blot was probed with Anti-GluR2/GluR3/GluR4 Polyclonal Antibody (Product # PA5-17314, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 100 kDa band corresponding to G... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17314
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues surrounding Ser720 of human GluR2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
79 µg/mL
规格
7.9 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AMPA receptor subunit GluA2; AMPA receptor subunit GluA3; AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; GluA4; GluR-2; GluR-3; GluR-4; GluR-B; GluR-C; GluR-D; GluR-K2; GluR-K3; GluR2; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; Glutamate receptor 4; glutamate receptor B; glutamate receptor C; glutamate receptor channel alpha 4; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; Glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA3 (alpha 3); glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1; unnamed protein product
基因别名: 2900064I19Rik; GluA2; GluA3; GluA4; GluA4-ATD; Glur-2; GluR-3; Glur-4; GluR-B; GLUR-C; GluR-D; GluR-K2; GLUR-K3; GLUR2; GLUR3; GLUR4; GLUR4C; Gluralpha3; Gluralpha4; GLURB; GLURC; GLURD; GRIA2; GRIA3; GRIA4; HBGR2; iGluR3; Kiaa4184; MRX94; MRXSW; NEDLIB; NEDSGA; spkw1
UniProt ID: (Rat) P19491, (Mouse) Q9Z2W9, (Rat) P19492, (Mouse) Q9Z2W8, (Rat) P19493
Entrez Gene ID: (Human) 2891, (Human) 2892, (Human) 2893, (Mouse) 14800, (Rat) 29627, (Mouse) 53623, (Rat) 29628, (Mouse) 14802, (Rat) 29629
beta-amyloid binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
protein binding
ligand-gated ion channel activity
signaling receptor activity
ligand-gated monoatomic cation channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
glutamate-gated calcium ion channel activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
receptor activity
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
ion transport
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
modulation of synaptic transmission
regulation of postsynaptic membrane potential
cation transmembrane transport
glutamate receptor signaling pathway
calcium-mediated signaling
protein homotetramerization
protein heterotetramerization
long-term synaptic potentiation
regulation of presynaptic membrane potential
negative regulation of smooth muscle cell apoptotic process
regulation of receptor recycling
transport
chemical synaptic transmission
receptor internalization
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
positive regulation of synaptic transmission, glutamatergic
regulation of synapse structure or activity
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