Search
Invitrogen
Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 5
Phospho-PI3K p85/p55 (Tyr458, Tyr199) Antibody (PA5-17387) in WB
Western blot analysis of Phospho-PI3K p85 pTyr458 /p55 pTyr199 in extracts from NIH/3T3-Src cells, untreated or treated with lambda phosphatase, using Phospho-PI3K p85 pTyr458 /p55 pTyr199 polyclonal antibody (Product # PA5-17387).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17387
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pTyr458 of mouse p85
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
190 µg/mL
规格
19 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
Phosphoinositide 3-kinase (PI3K, phospho PI3K) Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: OTTHUMP00000009783; OTTHUMP00000009784; p55PIK; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit beta; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3-kinase subunit p85-beta; PI3K regulatory subunit alpha; PI3K regulatory subunit beta; PI3K regulatory subunit gamma; polypeptide 3; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-beta; RP4-533D7.2
基因别名: AA414954; p50alpha; p55alpha; p55pik; p85alpha; p85beta; PI3K; Pik3r1; Pik3r2; Pik3r3
UniProt ID: (Mouse) P26450, (Mouse) O08908, (Mouse) Q64143
Entrez Gene ID: (Mouse) 18708, (Mouse) 18709, (Mouse) 18710
receptor binding
insulin receptor binding
insulin-like growth factor receptor binding
platelet-derived growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
calmodulin binding
protein C-terminus binding
transcription factor binding
1-phosphatidylinositol-3-kinase activity
protein kinase binding
protein phosphatase binding
protein domain specific binding
estrogen receptor binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
ErbB-3 class receptor binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
ATPase binding
phosphoprotein binding
kinase modulator
cellular glucose homeostasis
positive regulation of protein phosphorylation
negative regulation of cell-matrix adhesion
glucose metabolic process
protein phosphorylation
transport
negative regulation of cell adhesion
signal transduction
insulin receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of heart rate
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
phosphatidylinositol 3-kinase signaling
protein transport
negative regulation of cell-cell adhesion
B cell differentiation
positive regulation of cell migration
positive regulation of tumor necrosis factor production
response to insulin
cellular response to insulin stimulus
positive regulation of RNA splicing
cellular response to UV
response to endoplasmic reticulum stress
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
regulation of phosphatidylinositol 3-kinase activity
positive regulation of myoblast differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
negative regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
negative regulation of smooth muscle cell proliferation
protein stabilization
response to glucocorticoid
regulation of stress fiber assembly
NFAT protein import into nucleus
response to cAMP
growth hormone receptor signaling pathway
regulation of establishment of protein localization to plasma membrane
positive regulation of endoplasmic reticulum unfolded protein response
regulation of autophagy
regulation of actin filament polymerization
regulation of phosphorylation
positive regulation of cell adhesion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
