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Invitrogen
HP1 alpha Polyclonal Antibody
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图: 1 / 6
HP1 alpha Antibody (PA5-17441) in ICC/IF
Immunofluorescence analysis of Chromobox protein homolog 5 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with HP1 alpha Polyclonal Antibody (Product # PA5-17441) at 1:100 dilution in 0.1% BSA, incubated... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17441
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the carboxy terminus of human HP1alpha
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
120 µg/mL
规格
12 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with HP1 beta or HP1 gamma proteins.
靶标信息
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen p25; Cbx5 antibody; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; HGNC:1555; HP-1 alpha antibody; HP1 alpha; HP1Hs-alpha; mHP1(alpha)
基因别名: 2610029O15Rik; C75991; CBX5; HP1; HP1A; Hp1alpha
UniProt ID: (Mouse) Q61686
Entrez Gene ID: (Rat) 300266, (Mouse) 12419
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