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Invitrogen

PAK1/2/3 Polyclonal Antibody

View all (12) PAK1/2/3 antibodies

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PAK1/2/3 Polyclonal Antibody

Product Details

PA5-17789

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues at the carboxy-terminus of human PAK1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986982

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activated protein kinase alpha; ADRB2; adriamycin resistance-associated; alpha-PAK; aPAK; beta-PAK; BPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; CLAP; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; oligophrenin-3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; P21 CDKN1A-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21cdc42/rac1-activated serine/threonine kinase; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; PAK-1; PAK-2; PAK-3; PAK-a; PAK-B; PAK-y; protein kinase; protein kinase MUK2; S6/H4 kinase; serine/threonine-protein kinase PAK 2-like; STE20 homolog, yeast; unnamed protein product; yPAK

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Gene Aliases: 5330420P17Rik; A130002K10Rik; alpha-PAK; ARA; beta-PAK; bPAK; D16Ertd269e; gamma-PAK; IDDMSSD; KNO2; mKIAA4182; MRX30; MRX47; OPHN3; p65-PAK; PAK-1; PAK-2; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAKalpha; PAKgamma; Stk4; XLID30

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UniProt ID: (Human) Q13153, (Human) Q13177, (Human) O75914, (Rat) P35465, (Rat) Q64303, (Mouse) Q8CIN4, (Rat) Q62829, (Mouse) Q61036

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Entrez Gene ID: (Human) 5058, (Human) 5062, (Human) 5063, (Mouse) 18479, (Rat) 29431, (Rat) 29432, (Mouse) 224105, (Rat) 29433, (Mouse) 18481

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein binding collagen binding ATP binding protein kinase binding small GTPase binding identical protein binding gamma-tubulin binding protein serine kinase activity protein tyrosine kinase activator activity cadherin binding MAP kinase kinase activity MAP kinase kinase kinase activity GTPase binding
Process(es)
response to hypoxia chromatin remodeling protein phosphorylation cellular response to DNA damage stimulus neuromuscular junction development positive regulation of cell proliferation cellular response to starvation regulation of gene expression positive regulation of fibroblast migration dendrite development cell migration transmission of nerve impulse amygdala development establishment of cell polarity actin cytoskeleton organization positive regulation of cell migration positive regulation of microtubule polymerization cellular response to insulin stimulus regulation of actin cytoskeleton organization positive regulation of peptidyl-serine phosphorylation positive regulation of intracellular estrogen receptor signaling pathway intracellular signal transduction wound healing receptor clustering regulation of MAPK cascade positive regulation of axon extension positive regulation of insulin receptor signaling pathway protein autophosphorylation hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube neuron projection morphogenesis regulation of axonogenesis positive regulation of stress fiber assembly negative regulation of cell proliferation involved in contact inhibition dendritic spine development negative regulation of cell growth involved in cardiac muscle cell development gamma-aminobutyric acid secretion, neurotransmission glutamate secretion, neurotransmission positive regulation of microtubule nucleation positive regulation of protein targeting to membrane observational learning regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission regulation of long-term synaptic potentiation protein localization to cytoplasmic stress granule positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration cardiac muscle hypertrophy adherens junction assembly negative regulation of apoptotic process regulation of cytoskeleton organization negative regulation of stress fiber assembly bicellular tight junction assembly cellular response to transforming growth factor beta stimulus protein localization to cell-cell junction positive regulation of extrinsic apoptotic signaling pathway MAPK cascade stimulatory C-type lectin receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis regulation of actin filament polymerization ephrin receptor signaling pathway synapse organization dendritic spine morphogenesis regulation of actin filament organization small GTPase mediated signal transduction cerebellum development regulation of neuron projection development positive regulation of neuron apoptotic process positive regulation of dendritic spine morphogenesis regulation of postsynapse organization positive regulation of DNA biosynthetic process signal transduction vascular endothelial growth factor receptor signaling pathway protein maturation execution phase of apoptosis positive regulation of execution phase of apoptosis Fc-gamma receptor signaling pathway involved in phagocytosis
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