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Invitrogen
CRYAB Polyclonal Antibody
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CRYAB Antibody (PA5-18825) in WB
Western blot was performed using Anti-CRYAB Polyclonal Antibody (Product # PA5-18825) and a 20 kDa band corresponding to CRYAB was observed only in Mouse Eye and Rat Eye and not in any other tissues. Tissue extracts (30 µg lysate) of Mouse Eye (Lane 1), Rat Eye (Lane 2), Mouse Heart (Lane 3), Mouse Skeletal Muscle (Lane 4), Mouse Lung (Lane 5) and Mouse Liver (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-18825
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (RLEKDRFSVNLD) corresponding to the internal amino acids of CRYAB (aa 69-80).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
靶标信息
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; CryAB antibody; crystallin, alpha 2; Heat shock protein beta-5; heat shock protein CryAB; Heat shock protein family B member 5; heat shock protein HspB5; HspB5; P23; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
基因别名: AACRYA; Crya-2; CRYA2; CRYAB; HSPB5; P23
UniProt ID: (Rat) P23928, (Mouse) P23927
Entrez Gene ID: (Rat) 25420, (Mouse) 12955
response to hypoxia
lens development in camera-type eye
protein folding
tubulin complex assembly
muscle organ development
negative regulation of gene expression
regulation of cell death
negative regulation of cell growth
microtubule polymerization or depolymerization
negative regulation of intracellular transport
response to hydrogen peroxide
camera-type eye development
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein homooligomerization
stress-activated MAPK cascade
apoptotic process involved in morphogenesis
cellular response to gamma radiation
negative regulation of reactive oxygen species metabolic process
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