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SRGAP2 Polyclonal Antibody
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FIGURE: 1 / 2
SRGAP2 Antibody (PA5-19234) in ICC/IF
Immunocytochemistry analysis of SRGAP2 using SRGAP2 Polyclonal Antibody (Product # PA5-19234) (2.5 µg/mL in the right panel) in HEK293 overexpressing Human srGAP2. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong University.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19234
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KQEDRQTPRSPDST) corresponding to the internal amino acids of SRGAP2 (aa 197-211).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: formin-binding protein 2; rho GTPase-activating protein 34; SLIT-ROBO GAP2; unnamed protein product
Gene Aliases: ARHGAP34; FNBP2; SRGAP2A
UniProt ID: (Human) O75044
Entrez Gene ID: (Human) 23380
lamellipodium assembly involved in ameboidal cell migration
signal transduction
nervous system development
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
negative regulation of cell migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
regulation of small GTPase mediated signal transduction
regulation of synapse assembly
dendritic spine development
excitatory synapse assembly
inhibitory synapse assembly
negative regulation of neuron migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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