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Invitrogen
SATB2 Polyclonal Antibody
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图: 1 / 3
SATB2 Antibody (PA5-19630) in ICC/IF
Immunofluorescence analysis of SATB2 was performed using K-562 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SATB2 Polyclonal Antibody (Product # PA5-19630) at 3 µg/mL concentration in 0.1% BSA, incubated at 4 degree Celsius overnight and then with Goat anti-Rabbit IgG (Heavy Chain), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488 conjugate (Product # A27034) at a dilu... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-19630
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH derived from within residues 700 to the C-terminus of Mouse SATB2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.9 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA5-19630 targets SATB2 in IHC (F) and WB applications and shows reactivity with mouse and Rat samples.
The PA5-19630 immunogen is synthetic peptide conjugated to KLH derived from within residues 700 to the C-terminus of Mouse SATB2.
PA5-19630 detects SATB2 which has a predicted molecular weight of approximately 85 kDa.
靶标信息
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034-like DNA binding protein; MGC119474; MGC119477; Special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
基因别名: Kiaa1034; mKIAA1034; Satb2
UniProt ID: (Mouse) Q8VI24
Entrez Gene ID: (Mouse) 212712
negative regulation of transcription from RNA polymerase II promoter
neuron migration
osteoblast development
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
embryonic pattern specification
regulation of gene expression
chromatin modification
commitment of neuronal cell to specific neuron type in forebrain
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
cartilage development
palate development
cellular response to organic substance
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