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Invitrogen
Filamin A alpha-2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-29598
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Filamin A. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.42 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse kidney, PC-12, Rat2.
Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (98%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin binding protein 280; actin binding protein 280; involved in actin cytoskeleton organization; actin-binding protein 280; alpha-filamin; dilated pupils 2; endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; filamin A, alpha; filamin, alpha; filamin-1; non-muscle filamin; unnamed protein product
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; FGS2; filamin-1; FLN; FLN-A; FLN1; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD
UniProt ID: (Human) P21333, (Mouse) Q8BTM8
Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176
G-protein coupled receptor binding
RNA binding
protein binding
potassium channel regulator activity
kinase binding
small GTPase binding
Fc-gamma receptor I complex binding
protein homodimerization activity
ion channel binding
macromolecular complex binding
cadherin binding
SMAD binding
actin filament binding
GTPase binding
DNA-binding transcription factor binding
protein sequestering activity
protein kinase C binding
actin binding
angiogenesis
epithelial to mesenchymal transition
blood vessel remodeling
heart morphogenesis
adenylate cyclase-inhibiting dopamine receptor signaling pathway
negative regulation of neuron projection development
negative regulation of transcription from RNA polymerase I promoter
formation of radial glial scaffolds
cerebral cortex development
actin cytoskeleton organization
regulation of cell migration
regulation of actin filament bundle assembly
positive regulation of actin filament bundle assembly
protein localization to cell surface
negative regulation of protein catabolic process
positive regulation of protein import into nucleus
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
receptor clustering
wound healing, spreading of cells
early endosome to late endosome transport
establishment of protein localization
cell-cell junction organization
positive regulation of axon regeneration
synapse organization
protein stabilization
actin crosslink formation
cilium morphogenesis
semaphorin-plexin signaling pathway
protein localization to plasma membrane
tubulin deacetylation
mitotic spindle assembly
establishment of Sertoli cell barrier
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of potassium ion transmembrane transport
protein localization to bicellular tight junction
regulation of membrane repolarization during cardiac muscle cell action potential
positive regulation of neural precursor cell proliferation
positive regulation of integrin-mediated signaling pathway
positive regulation of neuron migration
blood coagulation, intrinsic pathway
positive regulation of platelet activation
megakaryocyte development
positive regulation of I-kappaB kinase/NF-kappaB signaling
release of sequestered calcium ion into cytosol
regulation of membrane repolarization during atrial cardiac muscle cell action potential
platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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