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          • Primary Antibodies ›
          • GATA2/GATA3 Antibodies

          Invitrogen

          GATA2/GATA3 Polyclonal Antibody

          View all (5) GATA2/GATA3 antibodies

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          Cite GATA2/GATA3 Polyclonal Antibody

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          • Antibody Testing Data (1)
          GATA2/GATA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          GATA2/GATA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 1

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          GATA2/GATA3 Antibody (PA5-36109) in IHC (P)

          Immunohistochemistry analysis of GATA2/GATA3 in paraffin-embedded human tonsil carcinoma tissue. Samples were incubated with GATA2/GATA3 polyclonal antibody (Product # PA5-36109) at a dilution of 1:50. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          GATA2/GATA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          GATA2/GATA3 Polyclonal Antibody

          Product Details

          PA5-36109

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to amino acids 270-318 of human GATA2
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2553373

          Product Specific Information

          Purity is >95% by SDS-PAGE.

          Target Information

          The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: GATA-3; GATA-binding factor 3; MGC2346; MGC5199; MGC5445; unnamed protein product

          View more View less

          Gene Aliases: DCML; Gata-2; Gata-3; HDR; HDRS; IMD21; jal; MONOMAC; NFE1B

          View more View less

          UniProt ID: (Human) P23769, (Human) P23771, (Mouse) O09100, (Mouse) P23772

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          Entrez Gene ID: (Human) 2624, (Human) 2625, (Mouse) 14461, (Mouse) 14462

          View more View less

          Function(s)
          RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding C2H2 zinc finger domain binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding interleukin-2 receptor binding identical protein binding E-box binding HMG box domain binding histone methyltransferase binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter neuron migration regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cytosolic calcium ion concentration anatomical structure morphogenesis positive regulation of gene expression negative regulation of gene expression cell differentiation response to lipid eosinophil fate commitment positive regulation of mast cell degranulation positive regulation of blood vessel endothelial cell migration cell fate commitment fat cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter system development positive regulation of phagocytosis regulation of developmental process positive regulation of phagocytosis, engulfment vascular wound healing positive regulation of cell migration involved in sprouting angiogenesis cochlea development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation negative regulation of endothelial cell apoptotic process cell morphogenesis in utero embryonic development cell fate determination cell activation type IV hypersensitivity regulation of cytokine production positive regulation of cytokine production kidney development mesonephros development lens development in camera-type eye immune system development pro-T cell differentiation aortic valve morphogenesis cardiac right ventricle morphogenesis ventricular septum development chromatin remodeling inflammatory response humoral immune response signal transduction nervous system development axon guidance negative regulation of cell proliferation male gonad development response to xenobiotic stimulus response to virus post-embryonic development positive regulation of signal transduction response to gamma radiation gene expression positive regulation of endothelial cell migration negative regulation of epithelial to mesenchymal transition regulation of neuron projection development neuron differentiation T cell differentiation erythrocyte differentiation macrophage differentiation regulation of epithelial cell differentiation TOR signaling negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production T cell differentiation in thymus negative regulation of mammary gland epithelial cell proliferation embryonic hemopoiesis cellular response to interferon-alpha ureter maturation parathyroid hormone secretion norepinephrine biosynthetic process inner ear morphogenesis regulation of CD4-positive, alpha-beta T cell differentiation protein kinase B signaling regulation of neuron apoptotic process ear development response to estrogen thymic T cell selection T-helper 2 cell differentiation response to ethanol positive regulation of T cell differentiation positive regulation of cell differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated cell maturation sympathetic nervous system development animal organ development thymus development embryonic organ development developmental growth anatomical structure formation involved in morphogenesis homeostasis of number of cells negative regulation of inflammatory response T cell receptor signaling pathway cartilage development regulation of multicellular organismal process positive regulation of protein kinase B signaling parathyroid gland development pharyngeal system development uterus development canonical Wnt signaling pathway mesenchymal to epithelial transition mast cell differentiation ureteric bud formation cellular response to cytokine stimulus cellular response to interleukin-4 cellular response to tumor necrosis factor otic vesicle development cellular response to BMP stimulus positive regulation of ureteric bud formation nephric duct morphogenesis nephric duct formation regulation of nephron tubule epithelial cell differentiation ureter morphogenesis lymphocyte migration regulation of establishment of cell polarity negative regulation of cell motility positive regulation of T-helper 2 cell cytokine production positive regulation of thyroid hormone generation positive regulation of transcription regulatory region DNA binding regulation of cellular response to X-ray urogenital system development embryonic placenta development regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development pituitary gland development somatic stem cell population maintenance negative regulation of fat cell differentiation negative regulation of myeloid cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation neuron fate commitment homeostasis of number of cells within a tissue definitive hemopoiesis semicircular canal development GABAergic neuron differentiation regulation of forebrain neuron differentiation defense response
          It has to be done as per old AB suggested Products section.

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