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Invitrogen
CaMKII beta/gamma Polyclonal Antibody
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FIGURE: 1 / 1
CaMKII beta/gamma Antibody (PA5-36195) in WB
Western blot analysis of CaMKII beta/gamma in Lane 1: U-87MG whole cell lysate (40 µg), Lane 2: PC3 whole cell lysate (40 µg), Lane 3: A549 whole cell lysate (40 µg), Lane 4: H9C2 whole cell lysate (40 µg), Lane 5: CT26 whole cell lysate (40 µg). Samples were incubated with CaMKII beta/gamma polyclonal antibody (Product # PA5-36195) at a dilution of 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36195
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 601-652of human CaMKII beta
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 50-80 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; beta M CaM kinase II; brain type II Ca2+/calmodulin-dependent protein kinase beta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca+2/calmodulin-dependent protein kinase II gamma; Ca2+/calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase; Calcium, calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; calcium/calmodulin-dependent protein kinase type II subunit gamma-like; calmodulin-dependent protein kinase II gamma subunit (EC 2.7.1.37); CaM kinase II beta subunit; caM kinase II subunit beta; caM kinase II subunit gamma; CaM-kinase II beta chain; caM-kinase II gamma chain; CaMK II; caMK-II subunit beta; caMK-II subunit gamma; Camk2 gamma; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product
Gene Aliases: CAM2; CAMK; CAMK-II; CAMK2; CAMKB; CAMKG; CaMKII; CaMKIIbeta; Ck2b; MRD54; MRD59
UniProt ID: (Human) Q13554, (Human) Q13555, (Rat) P08413, (Mouse) P28652, (Mouse) Q923T9, (Rat) P11730
Entrez Gene ID: (Human) 816, (Human) 818, (Rat) 24245, (Mouse) 12323, (Mouse) 12325, (Rat) 171140
protein kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
identical protein binding
protein homodimerization activity
protein serine kinase activity
calcium-dependent protein serine/threonine phosphatase activity
protein serine/threonine kinase activity
protein kinase binding
phospholipase binding
structural constituent of postsynaptic actin cytoskeleton
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
calcium ion transport
positive regulation of phospholipase activity
positive regulation of neuron projection development
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
response to cadmium ion
protein autophosphorylation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of dendritic spine morphogenesis
regulation of synapse maturation
positive regulation of synapse maturation
postsynaptic actin cytoskeleton organization
hippocampal neuron apoptotic process
regulation of protein localization to plasma membrane
cellular response to homocysteine
response to psychosocial stress
regulation of neuron migration
positive regulation of apoptotic signaling pathway
protein phosphorylation
signal transduction
regulation of skeletal muscle adaptation
regulation of synapse structural plasticity
regulation of calcium ion transport
regulation of dendritic spine development
response to hypoxia
response to oxidative stress
regulation of neuron projection development
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of relaxation of cardiac muscle
insulin secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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