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Invitrogen

Phospho-C/EBP alpha (Thr226) Polyclonal Antibody

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Phospho-C/EBP alpha (Thr226) Polyclonal Antibody

Product Details

PA5-36789

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide derived from human C/EBP alpha around the phosphorylation site of Threonine 226
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553735

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 30 and 45 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C EBP; C/EBP alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269

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Gene Aliases: C/EBP-alpha; C/ebpalpha; CBF-A; CEBP; CEBPA; DBPCEP

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UniProt ID: (Mouse) P53566, (Rat) P05554

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Entrez Gene ID: (Human) 1050, (Mouse) 12606, (Rat) 24252

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase I regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding kinase binding chromatin DNA binding identical protein binding protein homodimerization activity sequence-specific DNA binding protein heterodimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding HMG box domain binding STAT family protein binding DNA-binding transcription factor binding RNA polymerase I regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity transcription factor binding protein domain specific binding protein complex binding histone deacetylase binding transcription regulatory region DNA binding basic leucine zipper transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development generation of precursor metabolites and energy transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase I promoter negative regulation of cell proliferation positive regulation of gene expression cytokine-mediated signaling pathway myeloid cell differentiation lung development granulocyte differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process glucose homeostasis positive regulation of macrophage activation fat cell differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response regulation of cell cycle lipid homeostasis interleukin-6-mediated signaling pathway white fat cell proliferation energy homeostasis integrated stress response signaling positive regulation of DNA-templated transcription, initiation urea cycle embryonic placenta development transcription from RNA polymerase II promoter mitochondrion organization Notch signaling pathway multicellular organism development cholesterol metabolic process macrophage differentiation regulation of cell proliferation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase III promoter cell maturation inner ear development white fat cell differentiation brown fat cell differentiation cellular response to lithium ion cellular response to organic cyclic compound acute-phase response response to nutrient cell differentiation organ regeneration response to vitamin B2 response to glucocorticoid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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