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Invitrogen
INPP5E Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37119
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human INPP5E
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 72 kDa.
Purity is >95% by SDS-PAGE.
Target Information
INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase, 72 kDa; pharbin; phosphatidylinositol (4,5) bisphosphate 5-phosphatase homolog; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol 5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; unnamed protein product
Gene Aliases: 1200002L24Rik; 72kDa; CORS1; CPD4; JBTS1; mKIAA0123; MORMS; pharbin; PPI5PIV
UniProt ID: (Human) Q9NRR6, (Mouse) Q9JII1, (Rat) Q9WVR1
Entrez Gene ID: (Human) 56623, (Mouse) 64436, (Rat) 114089
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
protein binding
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate phosphatase activity
inositol phosphate phosphatase activity
negative regulation of translation
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol metabolic process
phosphatidylinositol dephosphorylation
negative regulation of protein kinase B signaling
cilium morphogenesis
response to inositol
negative regulation of protein localization to cilium
phosphatidylinositol biosynthetic process
phosphate-containing compound metabolic process
organophosphate metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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