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Invitrogen
Phospho-ZIPK (Thr265) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-40234
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human DAPK3 around the phosphorylation site of T265.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse and rat based on sequence homology.
靶标信息
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAP kinase 3; DAP-like kinase; DAP3K; death-associated kinase 3; Death-associated like kinase; Death-associated protein kinase 3; Dlk; MYPT1 kinase; unnamed protein product; ZIP kinase; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase
基因别名: DAPK3; Dapkl; DLK; ZIP; ZIPK
UniProt ID: (Rat) O88764, (Mouse) O54784
Entrez Gene ID: (Human) 1613, (Rat) 64391, (Mouse) 13144
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
cAMP response element binding protein binding
small GTPase binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
protein serine kinase activity
calmodulin-dependent protein kinase activity
Rho GTPase binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
regulation of smooth muscle contraction
regulation of mitotic nuclear division
regulation of mitotic cell cycle
regulation of cell shape
regulation of autophagy
negative regulation of translation
positive regulation of cell migration
regulation of actin cytoskeleton organization
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of myosin II filament organization
protein autophosphorylation
regulation of focal adhesion assembly
cellular response to interferon-gamma
positive regulation of canonical Wnt signaling pathway
regulation of cell motility
transcription, DNA-templated
chromatin modification
neuron differentiation
apoptotic signaling pathway
regulation of actin cytoskeleton reorganization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
phosphorylation
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